Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
3.
The Genetic Drivers of Juvenile, Young, and Early-Onset Parkinson's Disease in India.
Mov Disord
; 39(2): 339-349, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38014556
4.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord
; 38(3): 386-398, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36807624
5.
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.
Angew Chem Int Ed Engl
; 62(40): e202309306, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37582679
6.
High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II.
Int J Mol Sci
; 21(15)2020 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32751752
7.
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Hum Mol Genet
; 24(21): 6013-28, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26251043
8.
Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.
J Neurochem
; 129(5): 884-94, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24494600
9.
The role of ubiquitination in lysosomal trafficking of δ-opioid receptors.
Traffic
; 12(2): 170-84, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106040
10.
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Elife
; 122023 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874617
11.
Ubiquitination in the first cytoplasmic loop of µ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation.
J Biol Chem
; 286(46): 40193-204, 2011 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953467
12.
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
J Exp Med
; 219(3)2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35226042
13.
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Sci Transl Med
; 14(648): eabj2658, 2022 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675433
14.
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Sci Rep
; 11(1): 12900, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145320
15.
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
JCI Insight
; 6(19)2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34622797
16.
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits.
Sci Transl Med
; 12(540)2020 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321864
17.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461331
18.
Two regulatory mechanisms of monoterpenoid pheromone production in Ips spp. of bark beetles.
J Chem Ecol
; 35(6): 689-97, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19554371
19.
Regulation of endocytic clathrin dynamics by cargo ubiquitination.
Dev Cell
; 23(3): 519-32, 2012 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22940114
20.
Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes.
J Biol Chem
; 284(29): 19361-70, 2009 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19433584